Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness

Safety of tenofovir gel, a vaginal microbicide, in South African women: results of the CAPRISA 004 Trial.

Sokal, David C.
Abdool Karim, Quarraisha.
Sibeko, Sengeziwe.
Yende Zuma, Nonhlanhla.
Mansoor, Leila Essop.
Baxter, Cheryl.
Grobler, Anna Christina.
Fröhlich, Janet Ann.
Kharsany, Ayesha Bibi Mahomed.
Miya, Nomsa.
Mlisana, Koleka Patience.
Maarschalk, Silvia.
Abdool Karim, Salim Safurdeen.

January 2012

Background: Tenofovir gel, used vaginally before and after coitus, reduced women’s acquisition of HI...

Adherence in the CAPRISA 004 tenofovir gel microbicide trial.

Mansoor, Leila Essop.
Abdool Karim, Quarraisha.
Yende-Zuma, Fortunate Nonhlanhla.
MacQueen, Kathleen M.
Baxter, Cheryl.
Madlala, Bernadette T.
Grobler, Anneke.
Abdool Karim, Salim Safurdeen.

January 2014

CAPRISA, 2014.High adherence is key to microbicide effectiveness. Here we provide a description of a...

A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.

Gengiah, Tanuja Narayansamy.
Baxter, Cheryl.
Mansoor, Leila Essop.
Kharsany, Ayesha Bibi Mahomed.
Abdool Karim, Salim Safurdeen.

January 2011

Introduction: More than a million people acquire HIV infection annually. Pre-exposure prophylaxis (P...

Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness

Kashuba, Angela D. M.
Gengiah, Tanuja N.
Werner, Lise
Yang, Kuo-Hsiung
White, Nicole R.
Karim, Quarraisha A.
Abdool Karim, Salim S.

January 2015

The CAPRISA 004 trial showed that coitally-dosed tenofovir 1% gel reduced HIV acquisition by 39% ove...

J Acquir Immune Defic Syndr

ObjectiveThe CAPRISA 004 trial showed that coitally-dosed tenofovir 1% gel reduced HIV acquisition b...

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

Abdool Karim, Quarraisha
Abdool Karim, Salim
Frohlich, Janet A.
Grobler, Anneke C.
Baxter, Cheryl
Mansoor, Leila E.
Kharsany, Ayesha B. M.
Sibeko, Sengeziwe
Mlisana, Koleka P.
Omar, Zaheen
Gengiah, Tanuja N.
Maarschalk, Silvia
Arulappan, Natasha
Mlotshwa, Mukelisiwe
Morris, Lynn
Taylor, Douglas

January 2010

The CAPRISA 004 trial assessed effectiveness and safety of a 1% vaginal gel formulation of tenofovir...

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Abdool Karim, Salim Safurdeen.
Abdool Karim, Quarraisha.
Fröhlich, Janet Ann.
Grobler, Anna Christina.
Baxter, Cheryl.
Mansoor, Leila Essop.
Kharsany, Ayesha Bibi Mahomed.
Sibeko, Sengeziwe.
Mlisana, Koleka Patience.
Omar, Zaheen.
Gengiah, Tanuja Narayansamy.
Maarschalk, Silvia.
Arulappan, Natasha.
Mlotshwa, Mukelisiwe.
Morris, Lynn.
Taylor, Douglas.

January 2010

The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effecti...

Sensitive Tenofovir Resistance Screening of HIV-1 From the Genital and Blood Compartments of Women With Breakthrough Infections in the CAPRISA 004 Tenofovir Gel Trial

Wei, Xierong
Hunt, Gillian
Abdool Karim, Salim S.
Naranbhai, Vivek
Sibeko, Sengeziwe
Abdool Karim, Quarraisha
Li, Jin-fen
Kashuba, Angela D. M.
Werner, Lise
Passmore, Jo-Ann S.
Morris, Lynn
Heneine, Walid
Johnson, Jeffrey A.

January 2014

The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated t...

Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial.

Wei, Xierong.
Hunt, Gillian.
Abdool Karim, Salim Safurdeen.
Naranbhai, Vivek.
Sibeko, Sengeziwe.
Abdool Karim, Quarraisha.
Li, Jin-fen.
Kashuba, Angela D. M.
Werner, Lise.
Passmore, Jo-Ann Shelley.
Morris, Lynn.
Heneine, Walid.
Johnson, Jeffrey A.

January 2014

CAPRISA, 2014.The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study ...

SEE PROFILE

Janet A Frohlich
Cheryl Baxter
Leila E Mansoor
Koleka Mlisana

September 2016

The CAPRISA 004 trial assessed effectiveness and safety of a 1 % vaginal gel formulation of tenofovi...

CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck.

Valley-Omar, Ziyaad.
Sibeko, Sengeziwe.
Anderson, Jeffrey A.
Goodier, Sarah A.
Werner, Lise.
Arney, Leslie.
Naranbhai, Vivek.
Treurnicht, Florette K.
Abrahams, Melissa-Rose.
Bandawe, Gama P.
Swanstrom, Ronald.
Abdool Karim, Salim Safurdeen.
Abdool Karim, Quarraisha.
Williamson, Carolyn.

January 2011

Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a hu...

Preservation HIV-1–specific IFNg+ CD4+ T-Cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.

Mureithi, Marianne W.
Poole, Danielle.
Naranbhai, Vivek.
Reddy, Shabashini.
Mkhwanazi, Nompumelelo Prudence.
Sibeko, Sengeziwe.
Werner, Lise.
Abdool Karim, Quarraisha.
Abdool Karim, Salim Safurdeen.
Ndung'u, Peter Thumbi.
Altfeld, Marcus.

January 2011

Abstract: The Centre for the AIDS Program of Research in South Africa 004 trial demonstrated reducti...

A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.

Marla J Keller
Rebecca P Madan
N Merna Torres
Melissa J Fazzari
Sylvia Cho
Sabah Kalyoussef
Gail Shust
Pedro M M Mesquita
Nicolette Louissaint
Jianmeng Chen
Hillel W Cohen
Erin C Diament
Anna C Lee
Lydia Soto-Torres
Craig W Hendrix
Betsy C Herold

January 2011

Preclinical and early phase clinical microbicide studies have not consistently predicted the outcome...

Assessing Adherence in the CAPRISA 004 Tenofovir Gel HIV Prevention Trial: Results of a Nested Case–Control Study

MacQueen, Kathleen M.
Weaver, Mark A.
Van Loggerenberg, Francois
Succop, Stacey
Majola, Nelisle
Taylor, Doug
Karim, Quarraisha Abdool
Karim, Salim Abdool

January 2014

Adherence undeniably impacts product effectiveness in microbicide trials, but the connection has pro...

MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments

Hendrix, CW
Chen, BA
Guddera, V
Hoesley, C
Justman, J
Nakabiito, C
Salata, R
Soto-Torres, L
Patterson, K
Minnis, AM
Gandham, S
Gomez, K
Richardson, BA
Bumpus, NN

January 2013

Background: Oral and vaginal preparations of tenofovir as pre-exposure prophylaxis (PrEP) for human ...

Safety of tenofovir gel, a vaginal microbicide, in South African women: results of the CAPRISA 004 Trial.

Sokal, David C.
Abdool Karim, Quarraisha.
Sibeko, Sengeziwe.
Yende Zuma, Nonhlanhla.
Mansoor, Leila Essop.
Baxter, Cheryl.
Grobler, Anna Christina.
Fröhlich, Janet Ann.
Kharsany, Ayesha Bibi Mahomed.
Miya, Nomsa.
Mlisana, Koleka Patience.
Maarschalk, Silvia.
Abdool Karim, Salim Safurdeen.

January 2012

Background: Tenofovir gel, used vaginally before and after coitus, reduced women’s acquisition of HI...

Adherence in the CAPRISA 004 tenofovir gel microbicide trial.

Mansoor, Leila Essop.
Abdool Karim, Quarraisha.
Yende-Zuma, Fortunate Nonhlanhla.
MacQueen, Kathleen M.
Baxter, Cheryl.
Madlala, Bernadette T.
Grobler, Anneke.
Abdool Karim, Salim Safurdeen.

January 2014

CAPRISA, 2014.High adherence is key to microbicide effectiveness. Here we provide a description of a...

A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.

Gengiah, Tanuja Narayansamy.
Baxter, Cheryl.
Mansoor, Leila Essop.
Kharsany, Ayesha Bibi Mahomed.
Abdool Karim, Salim Safurdeen.

January 2011

Introduction: More than a million people acquire HIV infection annually. Pre-exposure prophylaxis (P...

Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness

Kashuba, Angela D. M.
Gengiah, Tanuja N.
Werner, Lise
Yang, Kuo-Hsiung
White, Nicole R.
Karim, Quarraisha A.
Abdool Karim, Salim S.

January 2015

The CAPRISA 004 trial showed that coitally-dosed tenofovir 1% gel reduced HIV acquisition by 39% ove...

J Acquir Immune Defic Syndr

ObjectiveThe CAPRISA 004 trial showed that coitally-dosed tenofovir 1% gel reduced HIV acquisition b...

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

Abdool Karim, Quarraisha
Abdool Karim, Salim
Frohlich, Janet A.
Grobler, Anneke C.
Baxter, Cheryl
Mansoor, Leila E.
Kharsany, Ayesha B. M.
Sibeko, Sengeziwe
Mlisana, Koleka P.
Omar, Zaheen
Gengiah, Tanuja N.
Maarschalk, Silvia
Arulappan, Natasha
Mlotshwa, Mukelisiwe
Morris, Lynn
Taylor, Douglas

January 2010

The CAPRISA 004 trial assessed effectiveness and safety of a 1% vaginal gel formulation of tenofovir...

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Abdool Karim, Salim Safurdeen.
Abdool Karim, Quarraisha.
Fröhlich, Janet Ann.
Grobler, Anna Christina.
Baxter, Cheryl.
Mansoor, Leila Essop.
Kharsany, Ayesha Bibi Mahomed.
Sibeko, Sengeziwe.
Mlisana, Koleka Patience.
Omar, Zaheen.
Gengiah, Tanuja Narayansamy.
Maarschalk, Silvia.
Arulappan, Natasha.
Mlotshwa, Mukelisiwe.
Morris, Lynn.
Taylor, Douglas.

January 2010

The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effecti...

Sensitive Tenofovir Resistance Screening of HIV-1 From the Genital and Blood Compartments of Women With Breakthrough Infections in the CAPRISA 004 Tenofovir Gel Trial

Wei, Xierong
Hunt, Gillian
Abdool Karim, Salim S.
Naranbhai, Vivek
Sibeko, Sengeziwe
Abdool Karim, Quarraisha
Li, Jin-fen
Kashuba, Angela D. M.
Werner, Lise
Passmore, Jo-Ann S.
Morris, Lynn
Heneine, Walid
Johnson, Jeffrey A.

January 2014

The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated t...

Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial.

Wei, Xierong.
Hunt, Gillian.
Abdool Karim, Salim Safurdeen.
Naranbhai, Vivek.
Sibeko, Sengeziwe.
Abdool Karim, Quarraisha.
Li, Jin-fen.
Kashuba, Angela D. M.
Werner, Lise.
Passmore, Jo-Ann Shelley.
Morris, Lynn.
Heneine, Walid.
Johnson, Jeffrey A.

January 2014

CAPRISA, 2014.The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study ...

SEE PROFILE

Janet A Frohlich
Cheryl Baxter
Leila E Mansoor
Koleka Mlisana

September 2016

The CAPRISA 004 trial assessed effectiveness and safety of a 1 % vaginal gel formulation of tenofovi...

CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck.

Valley-Omar, Ziyaad.
Sibeko, Sengeziwe.
Anderson, Jeffrey A.
Goodier, Sarah A.
Werner, Lise.
Arney, Leslie.
Naranbhai, Vivek.
Treurnicht, Florette K.
Abrahams, Melissa-Rose.
Bandawe, Gama P.
Swanstrom, Ronald.
Abdool Karim, Salim Safurdeen.
Abdool Karim, Quarraisha.
Williamson, Carolyn.

January 2011

Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a hu...

Preservation HIV-1–specific IFNg+ CD4+ T-Cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.

Mureithi, Marianne W.
Poole, Danielle.
Naranbhai, Vivek.
Reddy, Shabashini.
Mkhwanazi, Nompumelelo Prudence.
Sibeko, Sengeziwe.
Werner, Lise.
Abdool Karim, Quarraisha.
Abdool Karim, Salim Safurdeen.
Ndung'u, Peter Thumbi.
Altfeld, Marcus.

January 2011

Abstract: The Centre for the AIDS Program of Research in South Africa 004 trial demonstrated reducti...

A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.

Marla J Keller
Rebecca P Madan
N Merna Torres
Melissa J Fazzari
Sylvia Cho
Sabah Kalyoussef
Gail Shust
Pedro M M Mesquita
Nicolette Louissaint
Jianmeng Chen
Hillel W Cohen
Erin C Diament
Anna C Lee
Lydia Soto-Torres
Craig W Hendrix
Betsy C Herold

January 2011

Preclinical and early phase clinical microbicide studies have not consistently predicted the outcome...

Assessing Adherence in the CAPRISA 004 Tenofovir Gel HIV Prevention Trial: Results of a Nested Case–Control Study

MacQueen, Kathleen M.
Weaver, Mark A.
Van Loggerenberg, Francois
Succop, Stacey
Majola, Nelisle
Taylor, Doug
Karim, Quarraisha Abdool
Karim, Salim Abdool

January 2014

Adherence undeniably impacts product effectiveness in microbicide trials, but the connection has pro...

MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments

Hendrix, CW
Chen, BA
Guddera, V
Hoesley, C
Justman, J
Nakabiito, C
Salata, R
Soto-Torres, L
Patterson, K
Minnis, AM
Gandham, S
Gomez, K
Richardson, BA
Bumpus, NN

January 2013

Background: Oral and vaginal preparations of tenofovir as pre-exposure prophylaxis (PrEP) for human ...

Safety of tenofovir gel, a vaginal microbicide, in South African women: results of the CAPRISA 004 Trial.

Sokal, David C.
Abdool Karim, Quarraisha.
Sibeko, Sengeziwe.
Yende Zuma, Nonhlanhla.
Mansoor, Leila Essop.
Baxter, Cheryl.
Grobler, Anna Christina.
Fröhlich, Janet Ann.
Kharsany, Ayesha Bibi Mahomed.
Miya, Nomsa.
Mlisana, Koleka Patience.
Maarschalk, Silvia.
Abdool Karim, Salim Safurdeen.

January 2012

Background: Tenofovir gel, used vaginally before and after coitus, reduced women’s acquisition of HI...

Adherence in the CAPRISA 004 tenofovir gel microbicide trial.

Mansoor, Leila Essop.
Abdool Karim, Quarraisha.
Yende-Zuma, Fortunate Nonhlanhla.
MacQueen, Kathleen M.
Baxter, Cheryl.
Madlala, Bernadette T.
Grobler, Anneke.
Abdool Karim, Salim Safurdeen.

January 2014

CAPRISA, 2014.High adherence is key to microbicide effectiveness. Here we provide a description of a...

A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.

Gengiah, Tanuja Narayansamy.
Baxter, Cheryl.
Mansoor, Leila Essop.
Kharsany, Ayesha Bibi Mahomed.
Abdool Karim, Salim Safurdeen.

January 2011

Introduction: More than a million people acquire HIV infection annually. Pre-exposure prophylaxis (P...

Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness

Abstract

Extracted data

Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness

Abstract

Extracted data

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