Protein Binding of Lopinavir and Ritonavir During 4 Phases of Pregnancy: Implications for Treatment Guidelines
- Patterson, Kristine B.
- Dumond, Julie B.
- Prince, Heather A.
- Jenkins, Amanda J.
- Scarsi, Kimberly K.
- Wang, Ruili
- Malone, Stephanie
- Hudgens, Michael G.
- Kashuba, Angela D. M.
Publication date
January 2013
DOIAbstract
To investigate the intraindividual pharmacokinetics of total (protein bound + unbound) and unbound lopinavir/ritonavir (LPV/RTV) and to assess whether the pediatric formulation (100mg/25mg) can overcome any pregnancy-associated changes
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