A National Strategy to Develop Pragmatic Clinical Trials Infrastructure
- Concannon, Thomas W.
- Guise, Jeanne Marie
- Dolor, Rowena J.
- Meissner, Paul
- Tunis, Sean
- Krishnan, Jerry A.
- Pace, Wilson D.
- Saltz, Joel
- Hersh, William R.
- Michener, Lloyd
- Carey, Timothy S.
Publication date
January 2014
DOIAbstract
An important challenge in comparative effectiveness research is the lack of infrastructure to support pragmatic clinical trials, which compare interventions in usual practice settings and subjects. These trials present challenges that differ from those of classical efficacy trials, which are conducted under ideal circumstances, in patients selected for their suitability, and with highly controlled protocols
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