Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation
SummaryIn mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetran...
AbstractThe LKB1 tumor suppressor gene is frequently mutated in sporadic lung adenocarcinomas and ce...
cancer genetic alterations, studies defining the pathways deregulated in tumor progression and metas...
Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identi...
Germline mutations of the LKB1 gene are responsible for Peutz-Jeghers syndrome (PJS), an autosomal d...
Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz-Jeghers s...
LKB1 is the second most commonly altered tumour suppressor gene in lung adenocarcinoma, the most pre...
Introduction:Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer, an...
LKB1 is the second most commonly altered tumour suppressor gene in lung adenocarcinoma, the most pre...
Abstract LKB1/STK11 is a tumor suppressor gene that was originally identified in an a...
Germline mutations of the LKB1 tumor suppressor gene result in Peutz–Jeghers syndrome (PJS) charac-t...
Introduction:Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer, an...
Germline mutations of the LKB1 gene are responsible for Peutz-Jeghers syndrome (PJS), an autosomal d...
Germline mutations of the LKB1 gene are responsible for Peutz-Jeghers syndrome (PJS), an autosomal d...
SummaryIn mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetran...
SummaryIn mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetran...
AbstractThe LKB1 tumor suppressor gene is frequently mutated in sporadic lung adenocarcinomas and ce...
cancer genetic alterations, studies defining the pathways deregulated in tumor progression and metas...
Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identi...
Germline mutations of the LKB1 gene are responsible for Peutz-Jeghers syndrome (PJS), an autosomal d...
Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz-Jeghers s...
LKB1 is the second most commonly altered tumour suppressor gene in lung adenocarcinoma, the most pre...
Introduction:Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer, an...
LKB1 is the second most commonly altered tumour suppressor gene in lung adenocarcinoma, the most pre...
Abstract LKB1/STK11 is a tumor suppressor gene that was originally identified in an a...
Germline mutations of the LKB1 tumor suppressor gene result in Peutz–Jeghers syndrome (PJS) charac-t...
Introduction:Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer, an...
Germline mutations of the LKB1 gene are responsible for Peutz-Jeghers syndrome (PJS), an autosomal d...
Germline mutations of the LKB1 gene are responsible for Peutz-Jeghers syndrome (PJS), an autosomal d...
SummaryIn mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetran...
SummaryIn mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetran...
AbstractThe LKB1 tumor suppressor gene is frequently mutated in sporadic lung adenocarcinomas and ce...
cancer genetic alterations, studies defining the pathways deregulated in tumor progression and metas...
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