Ovarian Hormone Fluctuation, Neurosteroids, and HPA Axis Dysregulation in Perimenopausal Depression: A Novel Heuristic Model
- Gordon, Jennifer L.
- Girdler, Susan S.
- Meltzer-Brody, Samantha E.
- Stika, Catherine S.
- Thurston, Rebecca C.
- Clark, Crystal T.
- Prairie, Beth A.
- Moses-Kolko, Eydie
- Joffe, Hadine
- Wisner, Katherine L.
Publication date
January 2015
DOIAbstract
In this conceptual review, we propose a novel mechanistic candidate in the etiology of depression with onset in the menopause transition (a.k.a. perimenopausal depression) involving alterations in stress-responsive pathways, induced by ovarian hormone fluctuation
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