Altered Markers of Tonic Inhibition in the Dorsolateral Prefrontal Cortex of Subjects With Schizophrenia
- Maldonado-Avilés, Jaime G.
- Curley, Allison A.
- Hashimoto, Takanori
- Morrow, A. Leslie
- Ramsey, Amy J.
- O’Donnell, Patricio
- Volk, David W.
- Lewis, David A.
Publication date
January 2009
DOIAbstract
Cognitive impairments in schizophrenia are associated with lower expression of markers of γ-aminobutyric acid (GABA) synthesis in the prefrontal cortex. The effects of GABA are mediated by GABAA receptors that mediate either phasic or tonic inhibition. The authors assessed the expression of GABAA receptor α4 and δ subunits, which coassemble to form receptors mediating tonic inhibition, in schizophrenia
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