Fire sales and default contagion are two of the main drivers of systemic risk in financial networks. While default contagion spreads via direct balance sheet exposures between institutions, fire sales describe iterated distressed selling of assets and their associated decline in price which impacts all institutions invested in these assets. That is, institutions are indirectly linked if they have overlapping asset portfolios. In this paper, we develop a model that helps us understand the joint effect of the two contagion channels and investigate structures of financial systems that promote or hinder the spread of an initial local shock. We first consider the contagion process for an explicitly given system and then derive our main results f...