Circulating metabolites are associated with brain atrophy and white matter hyperintensities
- de Leeuw, F.A. (Francisca A.)
- Karamujić-Čomić, H. (Hata)
- Tijms, B.M. (Betty M.)
- Peeters, C.F.W. (Carel F.W.)
- Kester, M.I. (Maartje I.)
- Scheltens, P. (Philip)
- Ahmad, S. (Shahzad)
- Vojinović, D. (Dina)
- Adams, H.H.H. (Hieab)
- Hankemeier, T. (Thomas)
- Bos, D. (Daniel)
- Lugt, A. (Aad) van der
- Vernooij, M.W. (Meike)
- Ikram, M.A. (Arfan)
- Amin, N. (Najaf)
- Barkhof, F. (Frederik)
- Teunissen, C.E. (Charlotte)
- Duijn, C.M. (Cornelia) van
- Flier, W.M. (Wiesje) van der
DOIAbstract
Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and ...
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