Use of Hyperbaric Oxygen in Experimental Frost-Bite

Frost bite produced in rates by exposing them to -15 degree calcius and the extent of injury in the hind limbs and the tail was assessed at the end of 15 days. Hyperoxic treatment at normal atmospheric pressure and 1.5 atmosphere was given to experimental groups for 30 minutes daily for seven days in a hyperoxic chamber immediately after cold exposure. The controls were not given any treatment. Single oxygen treatment at normal atmosphere pressure was of no value, however, repeated hyperoxic treatment showed limited improvement but repeated treatment for seven days with hyperbaric oxygen at 1.5 atmosphere showed distinct recovery of frozen parts