This dissertation is based on the development of methods for statistical problems with inherent shape-restrictions and the inferential properties related to them. We discuss scientific phenomena which naturally give rise to monotonicity or concavity/convexity. Astronomical examples include the mass distribution of galaxies having a spherically symmetric and decreasing density. In the ubiquitous applications of function estimation in non-parametric scenarios, the shape-restriction improves the finite sample as well as asymptotic behavior when the true function itself has that restriction. Both density estimation and regression methodology can be developed along this line. Algorithms are devised to find estimators for Polya frequency function...