The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme that cleaves the amyloid-β protein precursor (AβPP), to generate the amyloid-β (Aβ) peptides, involved in Alzheimer’s Disease (AD). Other substrates of the γ-secretase, such as E-cadherin and Notch1, are involved in neurodevelopment and haematopoiesis. Gene-specific DNA methylation influences PSEN1 expression in AD animal models. Here we evaluated canonical and non-canonical cytosine methylation patterns of the PSEN1 5ʹ-flanking during brain development and AD progression, in DNA extracted from the frontal cortex of AD transgenic mice (TgCRND8) and post-mortem human brain. Mapping CpG and non-CpG methylation revealed different methylation pro...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme ...
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme ...
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme ...
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme ...
In recent years, in parallel with the growing awareness of the multifactorial nature of Late Onset A...
Late-onset Alzheimer's disease seems to be a multi-factorial disease with both genetic and non-genet...
The central nervous system has a pattern of gene expression that is closely regulated with respect t...
The central nervous system has a pattern of gene expression that is closely regulated with respect t...
Epigenetic mechanisms might be involved in Alzheimer's disease (AD). Genetic polymorphisms in severa...
The identification of Alzheimer's disease (AD) biomarkers is crucial to support drug discovery. With...
The MAPT gene is a risk locus for multiple neurodegenerative diseases, including idiopathic Parkinso...
The identification of Alzheimer's disease (AD) biomarkers is crucial to support drug discovery. With...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme ...
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme ...
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme ...
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme ...
In recent years, in parallel with the growing awareness of the multifactorial nature of Late Onset A...
Late-onset Alzheimer's disease seems to be a multi-factorial disease with both genetic and non-genet...
The central nervous system has a pattern of gene expression that is closely regulated with respect t...
The central nervous system has a pattern of gene expression that is closely regulated with respect t...
Epigenetic mechanisms might be involved in Alzheimer's disease (AD). Genetic polymorphisms in severa...
The identification of Alzheimer's disease (AD) biomarkers is crucial to support drug discovery. With...
The MAPT gene is a risk locus for multiple neurodegenerative diseases, including idiopathic Parkinso...
The identification of Alzheimer's disease (AD) biomarkers is crucial to support drug discovery. With...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state...