Temporal patterns of microglial activation when bilirubin enters into the brain
- Silva, SL
- Osório, CC
- Vaz, AR
- Barateiro, A
- Falcão, AS
- Brito, MA
- Fernandes, A
- Silva, RFM
- Brites, D
DOIAbstract
Microglia turns into an activated state when facing injury and disease entailing two main functions: phagocytosis of cellular debris and propagation of immune response. Once unconjugated bilirubin (UCB) increases proinflammatory cytokine secretion by both astrocytes [1] and microglia [2], we aimed to assess the sequence of events involved in microglia immunophenotype by UCB
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