Unconjugated bilirubin activates and damages microglia

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Falcao, AS
Fernandes, A
Brito, MA
Silva, RFM
Brites, D

January 2006

Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. The i...

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Falcao, AS
Fernandes, A
Brito, MA
Silva, RFM
Brites, D

January 2006

Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. The i...

Edited by:

Dora Brites
Jaime Kapitulnik
The Hebrew
Dora Brites
Faculdade De Farmácia

January 2012

doi: 10.3389/fphar.2012.00088 The evolving landscape of neurotoxicity by unconjugated bilirubin: rol...

Unconjugated bilirubin activates and damages microglia

Gordo, Ana C.
Falcao, Ana S.
Fernandes, Adelaide
Brito, Maria A.
Silva, Rui F. M.
Brites, Dora

January 2006

Microglia are the resident immune cells of the brain and are the principal source of cytokines produ...

Temporal patterns of microglial activation when bilirubin enters into the brain

Silva, SL
Osório, CC
Vaz, AR
Barateiro, A
Falcão, AS
Brito, MA
Fernandes, A
Silva, RFM
Brites, D

January 2009

Microglia turns into an activated state when facing injury and disease entailing two main functions:...

Temporal patterns of microglial activation when bilirubin enters into the brain

Silva, SL
Osório, CC
Vaz, AR
Barateiro, A
Falcão, AS
Brito, MA
Fernandes, A
Silva, RFM
Brites, D

January 2009

Microglia turns into an activated state when facing injury and disease entailing two main functions:...

Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin

Fernandes, Adelaide
Vaz, Ana Rita
Falcao, Ana S.
Silva, Rui F. M.
Brito, Maria A.
Brites, Dora

January 2007

The pathogenesis of bilirubin encephalopathy seems to result from accumulation of unconjugated bilir...

Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin

Fernandes, Adelaide
Vaz, Ana Rita
Falcao, Ana S.
Silva, Rui F. M.
Brito, Maria A.
Brites, Dora

January 2007

The pathogenesis of bilirubin encephalopathy seems to result from accumulation of unconjugated bilir...

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

Fernandes, A
Falcao, AS
Silva, RFM
Gordo, AC
Gama, MJ
Brito, MA
Brites, D

January 2006

During neonatal hyperbilirubinaemia, astrocytes activated by unconjugated bilirubin (UCB) may contib...

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

Fernandes, A
Falcao, AS
Silva, RFM
Gordo, AC
Gama, MJ
Brito, MA
Brites, D

January 2006

During neonatal hyperbilirubinaemia, astrocytes activated by unconjugated bilirubin (UCB) may contib...

Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells

Brito, Maria A.
Rosa, Alexandra I.
Falcao, Ana S.
Fernandes, Adelaide
Silva, Rui F. M.
Butterfield, D. Allan
Brites, Dora

January 2008

We investigated whether nerve cell damage by unconjugated bilirubin (UCB) is mediated by oxidative s...

Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin

Silva, RFM
Rodrigues, CMP
Brites, D

January 2002

High levels of unconjugated bilirubin (UCB) can be neurotoxic. Nevertheless, the mechanism of UCB in...

Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin

Silva, RFM
Rodrigues, CMP
Brites, D

January 2002

High levels of unconjugated bilirubin (UCB) can be neurotoxic. Nevertheless, the mechanism of UCB in...

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

Brito, Maria A.
Lima, Silvia
Fernandes, Adelaide
Falcao, Ana S.
Silva, Rui F. M.
Butterfield, D. Allan
Brites, Dora

January 2008

It is well established that high levels of unconjugated bilirubin (UCB) can be toxic to the central ...

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

Brito, Maria A.
Lima, Silvia
Fernandes, Adelaide
Falcao, Ana S.
Silva, Rui F. M.
Butterfield, D. Allan
Brites, Dora

January 2008

It is well established that high levels of unconjugated bilirubin (UCB) can be toxic to the central ...

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Falcao, AS
Fernandes, A
Brito, MA
Silva, RFM
Brites, D

January 2006

Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. The i...

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Falcao, AS
Fernandes, A
Brito, MA
Silva, RFM
Brites, D

January 2006

Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. The i...

Edited by:

Dora Brites
Jaime Kapitulnik
The Hebrew
Dora Brites
Faculdade De Farmácia

January 2012

doi: 10.3389/fphar.2012.00088 The evolving landscape of neurotoxicity by unconjugated bilirubin: rol...

Unconjugated bilirubin activates and damages microglia

Gordo, Ana C.
Falcao, Ana S.
Fernandes, Adelaide
Brito, Maria A.
Silva, Rui F. M.
Brites, Dora

January 2006

Microglia are the resident immune cells of the brain and are the principal source of cytokines produ...

Temporal patterns of microglial activation when bilirubin enters into the brain

Silva, SL
Osório, CC
Vaz, AR
Barateiro, A
Falcão, AS
Brito, MA
Fernandes, A
Silva, RFM
Brites, D

January 2009

Microglia turns into an activated state when facing injury and disease entailing two main functions:...

Temporal patterns of microglial activation when bilirubin enters into the brain

Silva, SL
Osório, CC
Vaz, AR
Barateiro, A
Falcão, AS
Brito, MA
Fernandes, A
Silva, RFM
Brites, D

January 2009

Microglia turns into an activated state when facing injury and disease entailing two main functions:...

Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin

Fernandes, Adelaide
Vaz, Ana Rita
Falcao, Ana S.
Silva, Rui F. M.
Brito, Maria A.
Brites, Dora

January 2007

The pathogenesis of bilirubin encephalopathy seems to result from accumulation of unconjugated bilir...

Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin

Fernandes, Adelaide
Vaz, Ana Rita
Falcao, Ana S.
Silva, Rui F. M.
Brito, Maria A.
Brites, Dora

January 2007

The pathogenesis of bilirubin encephalopathy seems to result from accumulation of unconjugated bilir...

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

Fernandes, A
Falcao, AS
Silva, RFM
Gordo, AC
Gama, MJ
Brito, MA
Brites, D

January 2006

During neonatal hyperbilirubinaemia, astrocytes activated by unconjugated bilirubin (UCB) may contib...

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

Fernandes, A
Falcao, AS
Silva, RFM
Gordo, AC
Gama, MJ
Brito, MA
Brites, D

January 2006

During neonatal hyperbilirubinaemia, astrocytes activated by unconjugated bilirubin (UCB) may contib...

Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells

Brito, Maria A.
Rosa, Alexandra I.
Falcao, Ana S.
Fernandes, Adelaide
Silva, Rui F. M.
Butterfield, D. Allan
Brites, Dora

January 2008

We investigated whether nerve cell damage by unconjugated bilirubin (UCB) is mediated by oxidative s...

Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin

Silva, RFM
Rodrigues, CMP
Brites, D

January 2002

High levels of unconjugated bilirubin (UCB) can be neurotoxic. Nevertheless, the mechanism of UCB in...

Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin

Silva, RFM
Rodrigues, CMP
Brites, D

January 2002

High levels of unconjugated bilirubin (UCB) can be neurotoxic. Nevertheless, the mechanism of UCB in...

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

Brito, Maria A.
Lima, Silvia
Fernandes, Adelaide
Falcao, Ana S.
Silva, Rui F. M.
Butterfield, D. Allan
Brites, Dora

January 2008

It is well established that high levels of unconjugated bilirubin (UCB) can be toxic to the central ...

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid

Brito, Maria A.
Lima, Silvia
Fernandes, Adelaide
Falcao, Ana S.
Silva, Rui F. M.
Butterfield, D. Allan
Brites, Dora

January 2008

It is well established that high levels of unconjugated bilirubin (UCB) can be toxic to the central ...

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Falcao, AS
Fernandes, A
Brito, MA
Silva, RFM
Brites, D

January 2006

Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. The i...

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Falcao, AS
Fernandes, A
Brito, MA
Silva, RFM
Brites, D

January 2006

Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. The i...

Edited by:

Dora Brites
Jaime Kapitulnik
The Hebrew
Dora Brites
Faculdade De Farmácia

January 2012

doi: 10.3389/fphar.2012.00088 The evolving landscape of neurotoxicity by unconjugated bilirubin: rol...

Unconjugated bilirubin activates and damages microglia

Abstract

Extracted data

Unconjugated bilirubin activates and damages microglia

Abstract

Extracted data

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