The femtosecond laser technology is emerging as a powerful and flexible tool for the fabrication of miniaturized polymeric devices, thanks to the micrometric precision and the minimum thermal damage on the workpiece obtainable through ultrafast laser ablation. However, parametrization of femtosecond laser processes is often based on a trial and error approach, which requires a lot of expensive experimental efforts. The design of experiment (DoE) approach can offer a methodical way to quickly determine the laser process settings limiting the use of resources. In this work, we define an accurate DoE procedure to estimate the influence of the laser repetition rate, pulse energy, scanning speed, and hatch distance on the fs-laser micromilling p...