This dissertation consists of three distinct, although conceptually related, public sector topics: the Transportation Security Agency (TSA), U.S. Customs and Border Patrol (CBP), and the Georgia Trauma Care Network Commission (GTCNC). The topics are unified in their mathematical modeling and mixed-integer programming solution strategies. In Chapter 2, we discuss strategies for solving large-scale integer programs to include column generation and the known heuristic of particle swarm optimization (PSO). In order to solve problems with an exponential number of decision variables, we employ Dantzig-Wolfe decomposition to take advantage of the special subproblem structures encountered in resource allocation problems. In each of the resource all...