The “Exclusion Argument” of J. Kim and others motivates mind-body reductionism by arguing that antireductionism leads to epiphenomenalism about the mental, which conflicts with standard causal views of actions. Some critics think the argument’s assumptions about causation and explanation lack support in scientific practice. In four papers this dissertation uses considerations of neuroscience to address such objections. (1) Contra B. Loewer it argues that while causal exclusion does presuppose a “productive” view of causation, this view is scientifically respectable, because it is part of mechanistic explanations in neuroscience. (2) Contra T. Burge’s explanatory pluralism it shows that the differences between psychological and neurosc...