A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine
- Cottrell, MacKenzie L.
- Yang, Kuo H.
- Prince, Heather M. A.
- Sykes, Craig
- White, Nicole
- Malone, Stephanie
- Dellon, Evan S.
- Madanick, Ryan D.
- Shaheen, Nicholas J.
- Hudgens, Michael G.
- Wulff, Jacob
- Patterson, Kristine B.
- Nelson, Julie A. E.
- Kashuba, Angela D. M.
DOIAbstract
Background. A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses required for effective human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP)
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