Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial
- Madanitsa, Mwayiwawo
- Kalilani, Linda
- Mwapasa, Victor
- van Eijk, Anna M.
- Khairallah, Carole
- Ali, Doreen
- Pace, Cheryl
- Smedley, James
- Thwai, Kyaw-Lay
- Levitt, Brandt
- Wang, Duolao
- Kang’ombe, Arthur
- Faragher, Brian
- Taylor, Steve M.
- Meshnick, Steve
- ter Kuile, Feiko O.
DOIAbstract
In Africa, most plasmodium infections during pregnancy remain asymptomatic, yet are associated with maternal anemia and low birthweight. WHO recommends intermittent preventive therapy in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). However, sulfadoxine-pyrimethamine (SP) efficacy is threatened by high-level parasite resistance. We conducted a trial to evaluate the efficacy and safety of scheduled intermittent screening with malaria rapid diagnostic tests (RDTs) and treatment of RDT-positive women with dihydroartemisinin-piperaquine (DP) as an alternative strategy to IPTp-SP
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