Add to ORKGThree small cluster oligosaccharide mimetics were synthesized, and their CDCl3 solution conformations were determined with NMR experiments. In this paper, we confirmed conformational similarities in rings A and B in all three compounds, and we provide the overall solution geometries. In all cases, an unusual cyclohexane twist-boat conformation with longrange 4 J-(W)-coupling was observed. The origin of the bias towards the twist-boat was attributed primarily to the fused ring system between the cyclohexane ring and the dioxacyclopentane (acetal) including hydrogen bonding. Temperature-annealed molecular dynamics simulations complemented the NMR experiments and supported the overall assignment
The conformation of saccharides in solution is challenging to characterize in the context of a singl...
A tricyclic ketone with seven stereogenic centers produced in >95:5 diastereomeric excess by an asym...
Understanding the factors that determine molecular shape enables scientists to begin to understand a...
The synthesis of amide-linked disaccharide mimetics has been explored starting with carbohydrate-bas...
Advances in the elaboration of vaccines and enzyme inhibitors rely on acquiring more knowledge about...
Conformations of the α-L-Rhap(1-2)[β-D-Galp(1-3)]-β-D-Glc1-OMe disaccharides and the ...
Glycosylation of molecules improve their pharmacological and pharmacokinetic properties. In the curr...
The conformational preferences of several oligosaccharides are investigated herein using a combinati...
The three-dimensional conformations of various oligosaccharides have been investigated using high-re...
Oligosaccharides constitute important recognition motifs for fundamental biological processes such a...
The intrinsic flexibility of glycans complicates the study of their structures and dynamics, which a...
A deeper understanding of the diversity of carbohydrates and the many applications of oligo- and pol...
The authors would like to acknowledge the EPSRC for funding.Determining the conformational preferenc...
Conformations of the α-l-Rhap(1-2)-β-d-Glc1-OMe and β-d-Galp(1-3)-β-d-Glc1-OMe disaccharides and the...
The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the confor...
The conformation of saccharides in solution is challenging to characterize in the context of a singl...
A tricyclic ketone with seven stereogenic centers produced in >95:5 diastereomeric excess by an asym...
Understanding the factors that determine molecular shape enables scientists to begin to understand a...
The synthesis of amide-linked disaccharide mimetics has been explored starting with carbohydrate-bas...
Advances in the elaboration of vaccines and enzyme inhibitors rely on acquiring more knowledge about...
Conformations of the α-L-Rhap(1-2)[β-D-Galp(1-3)]-β-D-Glc1-OMe disaccharides and the ...
Glycosylation of molecules improve their pharmacological and pharmacokinetic properties. In the curr...
The conformational preferences of several oligosaccharides are investigated herein using a combinati...
The three-dimensional conformations of various oligosaccharides have been investigated using high-re...
Oligosaccharides constitute important recognition motifs for fundamental biological processes such a...
The intrinsic flexibility of glycans complicates the study of their structures and dynamics, which a...
A deeper understanding of the diversity of carbohydrates and the many applications of oligo- and pol...
The authors would like to acknowledge the EPSRC for funding.Determining the conformational preferenc...
Conformations of the α-l-Rhap(1-2)-β-d-Glc1-OMe and β-d-Galp(1-3)-β-d-Glc1-OMe disaccharides and the...
The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the confor...
The conformation of saccharides in solution is challenging to characterize in the context of a singl...
A tricyclic ketone with seven stereogenic centers produced in >95:5 diastereomeric excess by an asym...
Understanding the factors that determine molecular shape enables scientists to begin to understand a...