Reaction of a 2β-bromomethyl penam with triphenyltin hydride gave, via ring expansion of the derived 2β-methyl radical, the corresponding cepham system; a similar process may be in operation during the biosynthetic ring expansion of penicillin N to deacetoxycephalasporin C.1. © 1988
The mechanism of penicillin formation through the action of the enzyme isopenicillin N synthase (IPN...
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
The C6 side-chain of complex carbapenem antibiotics not only distinguish this class from other β-la...
Structural variants of the acylamino side chain of penicillins have been tested as substrates for De...
The order of events in the Deacetoxycephalosporin C/Deacetylcephalosporrn C Synthetase (DAOC/DAC Syn...
Incubation of penicillin N (3a) with partially purified deacetoxy/deacetylcephalosporin C synthase (...
Cephalosporolide B (Ces-B) was efficiently synthesized and exploited for the first time as a versati...
Bromination of cepham I with 2,6-lutidine Br complex gave II (R = Br), which was treated with DMF/H2...
The p-nitrobenzoates I were stereospecifically transformed with AgOAc-AcOH into the penam derivs. II...
Reaction of a 1:1 mixture of penicillin N and 2,2-bis(trideuteriomethyl) penicillin N with partially...
Penicillins and cephalosporins are b-lactam antibiot-ics widely used in human medicine. The biosynth...
Two practical routes to (6S,7S)-cephalosporins from 6-aminopenicillanic acid (6-APA) are described. ...
This thesis reports the work done on two research projects which were carried out independently of e...
The C4 benzoyloxy substituted β-lactams (65)-(68) were formed by the copper-promoted reaction of β-l...
The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, i...
The mechanism of penicillin formation through the action of the enzyme isopenicillin N synthase (IPN...
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
The C6 side-chain of complex carbapenem antibiotics not only distinguish this class from other β-la...
Structural variants of the acylamino side chain of penicillins have been tested as substrates for De...
The order of events in the Deacetoxycephalosporin C/Deacetylcephalosporrn C Synthetase (DAOC/DAC Syn...
Incubation of penicillin N (3a) with partially purified deacetoxy/deacetylcephalosporin C synthase (...
Cephalosporolide B (Ces-B) was efficiently synthesized and exploited for the first time as a versati...
Bromination of cepham I with 2,6-lutidine Br complex gave II (R = Br), which was treated with DMF/H2...
The p-nitrobenzoates I were stereospecifically transformed with AgOAc-AcOH into the penam derivs. II...
Reaction of a 1:1 mixture of penicillin N and 2,2-bis(trideuteriomethyl) penicillin N with partially...
Penicillins and cephalosporins are b-lactam antibiot-ics widely used in human medicine. The biosynth...
Two practical routes to (6S,7S)-cephalosporins from 6-aminopenicillanic acid (6-APA) are described. ...
This thesis reports the work done on two research projects which were carried out independently of e...
The C4 benzoyloxy substituted β-lactams (65)-(68) were formed by the copper-promoted reaction of β-l...
The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, i...
The mechanism of penicillin formation through the action of the enzyme isopenicillin N synthase (IPN...
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
The C6 side-chain of complex carbapenem antibiotics not only distinguish this class from other β-la...
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