In this thesis, a portfolio optimization with integer variables which influence optimal assets allocation in domestic as well as in international environment, is studied. At the beginning with basic terms, assets and portfolio background, incentives of portfolio creation, fields of portfolio application and portfolio management is dealt. Following the characteristics of assets and portfolios (expected return, risk, liquidity), which are used by investors to value their properties, are introduced. Next the mean-risk models are derived for the measures of risk - variance, Value at Risk, Conditional Value at Risk and prepared for a practical application. Heuristics implemented in Matlab and standard algorithms of software GAMS are used for sol...