This thesis studies the prolyl-hydroxylase family of 2-oxoglutarate dependent oxygenases from structural, functional and evolutionary perspectives. The role of prolyl-hydroxylation was first identified in collagen, wherein hydroxyproline was found to stabilise the collagen triple helix. In the 1960s, the presence of hydroxyproline in collagen was found to be a result of enzyme catalysed protein modification. An enzyme, now known as collagen prolyl-4-hydroxylase (CP4H), was found to be completely dependent on Fe(II), 2-oxoglutarate (2OG) and molecular oxygen for catalysis, and was the inaugural member of enzyme family known as the Fe(II) and 2OG-dependent oxygenases (2OG oxygenases), the members of which have since expanded dramatically ...
The collagen proteins are the principal component of the extracellular matrix and are the most abun...
Post-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and ferrous ...
SummaryPost-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and f...
This thesis studies the prolyl-hydroxylase family of 2-oxoglutarate dependent oxygenases from struct...
Significance The Fe(II)- and 2-oxoglutarate (2OG)-dependent hypoxia-inducible...
The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabi...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
Oxygen dependent prolyl-4-hydroxylation of the alpha-subunit of the hypoxia inducible transcription ...
The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabi...
Abstract HIF prolyl 4-hydroxylases (HIF-P4Hs) and HIF asparaginyl hydroxylase (FIH) are novel member...
The oxygen-dependent hydroxylation of proline residues in the a subunit of hypoxia-inducible transcr...
SummaryPost-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and f...
The work described in this thesis focused on 2-oxoacid-dependent oxygenase enzymes. Most of the work...
Background: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducib...
The collagen proteins are the principal component of the extracellular matrix and are the most abun...
Post-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and ferrous ...
SummaryPost-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and f...
This thesis studies the prolyl-hydroxylase family of 2-oxoglutarate dependent oxygenases from struct...
Significance The Fe(II)- and 2-oxoglutarate (2OG)-dependent hypoxia-inducible...
The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabi...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
Oxygen dependent prolyl-4-hydroxylation of the alpha-subunit of the hypoxia inducible transcription ...
The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabi...
Abstract HIF prolyl 4-hydroxylases (HIF-P4Hs) and HIF asparaginyl hydroxylase (FIH) are novel member...
The oxygen-dependent hydroxylation of proline residues in the a subunit of hypoxia-inducible transcr...
SummaryPost-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and f...
The work described in this thesis focused on 2-oxoacid-dependent oxygenase enzymes. Most of the work...
Background: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducib...
The collagen proteins are the principal component of the extracellular matrix and are the most abun...
Post-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and ferrous ...
SummaryPost-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and f...