Abstract HIF prolyl 4-hydroxylases (HIF-P4Hs) and HIF asparaginyl hydroxylase (FIH) are novel members of the 2-oxoglutarate dioxygenase family that play key roles in the regulation of the hypoxia-inducible transcription factor (HIF). They hydroxylate specific proline and asparagine residues in HIF-α, leading to its proteasomal degradation and inhibition of its transcriptional activity, respectively. These enzymes are inhibited in hypoxia, and as a consequence HIF-α becomes stabilized, forms a dimer with HIF-β, attains its maximal transcriptional activity and induces expression of many genes that are important for cell survival under hypoxic conditions. The three HIF-P4Hs and FIH were expressed here as recombinant proteins in insect cells a...
Oxygen dependent prolyl-4-hydroxylation of the alpha-subunit of the hypoxia inducible transcription ...
This thesis studies the prolyl-hydroxylase family of 2-oxoglutarate dependent oxygenases from struct...
Factor inhibiting hypoxia-inducible factor (FIH) is a JmjC domain 2-oxogluarate and Fe(II)-dependent...
Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular ...
Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular ...
Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulate...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF...
The hypoxia-inducible factor (HIF) is a key regulator of transcriptional responses to hypoxia in ani...
The adaptation of animals to oxygen availability is mediated by a transcription factor termed hypoxi...
The hypoxia-inducible factor (HIF) family of transcription factors is responsible for coordinating t...
The prolyl-4-hydroxylases (PHD) are oxygen sensors that measure oxygen fluctuations in cells. Under ...
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that directs a broad range of...
All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to adapt t...
Hypoxia inducible factor (HIF) is an alpha/beta heterodimeric transcriptional complex that plays a k...
Oxygen dependent prolyl-4-hydroxylation of the alpha-subunit of the hypoxia inducible transcription ...
This thesis studies the prolyl-hydroxylase family of 2-oxoglutarate dependent oxygenases from struct...
Factor inhibiting hypoxia-inducible factor (FIH) is a JmjC domain 2-oxogluarate and Fe(II)-dependent...
Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular ...
Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular ...
Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulate...
In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible trans...
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF...
The hypoxia-inducible factor (HIF) is a key regulator of transcriptional responses to hypoxia in ani...
The adaptation of animals to oxygen availability is mediated by a transcription factor termed hypoxi...
The hypoxia-inducible factor (HIF) family of transcription factors is responsible for coordinating t...
The prolyl-4-hydroxylases (PHD) are oxygen sensors that measure oxygen fluctuations in cells. Under ...
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that directs a broad range of...
All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to adapt t...
Hypoxia inducible factor (HIF) is an alpha/beta heterodimeric transcriptional complex that plays a k...
Oxygen dependent prolyl-4-hydroxylation of the alpha-subunit of the hypoxia inducible transcription ...
This thesis studies the prolyl-hydroxylase family of 2-oxoglutarate dependent oxygenases from struct...
Factor inhibiting hypoxia-inducible factor (FIH) is a JmjC domain 2-oxogluarate and Fe(II)-dependent...