A tandem Michael addition-enolate alkylation followed by Dieckmann cyclization and Beckmann rearrangement provided the corresponding [5.4.0] azaspirobicyclodecane, a key intermediate in our synthetic route to the marine alkaloid halichlorine (1).781617161
Marine natural products have long served as promising compounds and scaffolds for new therapeutic ag...
Access restricted to the OSU CommunityDiscussed herein is the evolution of the strategies for the sy...
Investigations related to semipinacol rearrangements for the formation of 1-azaspirocycles includin...
[reaction: see text] A tandem Michael addition-enolate alkylation followed by Dieckmann cyclization ...
This document describes a synthetic approach towards the tricyclic unit contained within the natural...
Azaspirocycles are found as structural motif in a number of highly interesting natural products. In ...
The enantioselective synthesis (3.7% overall yield in nine steps from 2) and biological screening of...
Halichlorine, pinnaic acid and pinnarine are a novel family of marine alkaloids, characterised by th...
A new three-step route to azaspirocycles involving the organolithium-mediated conversion of beta-alk...
The work presented in this thesis describes the efforts towards the understanding of a novel sequent...
Graduation date: 2013Azaspiracid-1, a novel marine toxin that contains 9 rings and 20 stereogenic ce...
LiNH2BH3-promoted reductive opening of 8-substituted phenylglycinol-derived oxazolopiperidone lactam...
This thesis is split into 4 sections, and is concerned with the development of a biomimetic total sy...
Abstract: The development of a new one-pot reaction sequence afforded the tricyclic core of several ...
X-Ray crystallography establishes that the marine alkaloids ()-haliclonacyclamine A 1 and (+)-halicl...
Marine natural products have long served as promising compounds and scaffolds for new therapeutic ag...
Access restricted to the OSU CommunityDiscussed herein is the evolution of the strategies for the sy...
Investigations related to semipinacol rearrangements for the formation of 1-azaspirocycles includin...
[reaction: see text] A tandem Michael addition-enolate alkylation followed by Dieckmann cyclization ...
This document describes a synthetic approach towards the tricyclic unit contained within the natural...
Azaspirocycles are found as structural motif in a number of highly interesting natural products. In ...
The enantioselective synthesis (3.7% overall yield in nine steps from 2) and biological screening of...
Halichlorine, pinnaic acid and pinnarine are a novel family of marine alkaloids, characterised by th...
A new three-step route to azaspirocycles involving the organolithium-mediated conversion of beta-alk...
The work presented in this thesis describes the efforts towards the understanding of a novel sequent...
Graduation date: 2013Azaspiracid-1, a novel marine toxin that contains 9 rings and 20 stereogenic ce...
LiNH2BH3-promoted reductive opening of 8-substituted phenylglycinol-derived oxazolopiperidone lactam...
This thesis is split into 4 sections, and is concerned with the development of a biomimetic total sy...
Abstract: The development of a new one-pot reaction sequence afforded the tricyclic core of several ...
X-Ray crystallography establishes that the marine alkaloids ()-haliclonacyclamine A 1 and (+)-halicl...
Marine natural products have long served as promising compounds and scaffolds for new therapeutic ag...
Access restricted to the OSU CommunityDiscussed herein is the evolution of the strategies for the sy...
Investigations related to semipinacol rearrangements for the formation of 1-azaspirocycles includin...
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