Tripterygium wilfordii has long been used as a medicinal plant, and exhibits impressive and effective anti-inflammatory, immunosuppressive and anti-tumor activities. The main active ingredients are diterpenoids and triterpenoids, such as triptolide and celastrol, respectively. A major challenge to harnessing these natural products is that they are found in very low amounts in planta. Access has been further limited by the lack of knowledge regarding the underlying biosynthetic pathways, particularly for the abeo-abietane tri-epoxide lactone triptolide. Here suspension cell cultures of T. wilfordii were found to produce triptolide in an inducible fashion, with feeding studies indicating that miltiradiene is the relevant abietane olefin precu...
Fig. 1. Chemical structures of compounds 1–11.Published as part of Hu, Ya-Lin, Xu, Tian-Qi, Cheng, H...
Farnesylpyrophosphate synthase (FPS) catalyzes the biosynthesis of farnesyl pyrophos-phate (FPP), wh...
Hu, Ya-Lin, Xu, Tian-Qi, Cheng, Huai-Yu, Liu, Ying, Zhang, Xia, Zhang, Yu-Bo, Zhou, Guang-Xiong (202...
Adventitious root cultures were developed from Tripterygium regelii Sprague & Takeda and growth cond...
This thesis is concerned with the use of plant cell cultures in combination with organic synthesis ...
We found triptolide synthesis is correlated with the expressions of TwGGPPS1 and TwGGPPS4 . This lay...
We found triptolide synthesis is correlated with the expressions of TwGGPPS1 and TwGGPPS4 . This lay...
In a program aimed at the identification of compounds responsible for the immunosuppressive and anti...
The growth of cell suspensions of the Asian medicinal plant Tripterygium wilfordii was manipulated i...
The growth of cell suspensions of the Asian medicinal plant Tripterygium wilfordii was manipulated i...
1-Deoxy-d-xylulose-5-phosphate synthase (DXS) and 1-deoxy-d-xylulose-5-phosphate reductoisomerase (D...
The development of medical applications exploiting the broad bioactivities of the diterpene therapeu...
Triptolide is a trace natural product of Tripterygium wilfordii. It has antitumor activities, partic...
1. Bioactive compounds from medicinal plants with anticancer and anti-inflammatory effects have beco...
1-Deoxy-d-xylulose-5-phosphate synthase (DXS) and 1-deoxy-d-xylulose-5-phosphate reductoisomerase (D...
Fig. 1. Chemical structures of compounds 1–11.Published as part of Hu, Ya-Lin, Xu, Tian-Qi, Cheng, H...
Farnesylpyrophosphate synthase (FPS) catalyzes the biosynthesis of farnesyl pyrophos-phate (FPP), wh...
Hu, Ya-Lin, Xu, Tian-Qi, Cheng, Huai-Yu, Liu, Ying, Zhang, Xia, Zhang, Yu-Bo, Zhou, Guang-Xiong (202...
Adventitious root cultures were developed from Tripterygium regelii Sprague & Takeda and growth cond...
This thesis is concerned with the use of plant cell cultures in combination with organic synthesis ...
We found triptolide synthesis is correlated with the expressions of TwGGPPS1 and TwGGPPS4 . This lay...
We found triptolide synthesis is correlated with the expressions of TwGGPPS1 and TwGGPPS4 . This lay...
In a program aimed at the identification of compounds responsible for the immunosuppressive and anti...
The growth of cell suspensions of the Asian medicinal plant Tripterygium wilfordii was manipulated i...
The growth of cell suspensions of the Asian medicinal plant Tripterygium wilfordii was manipulated i...
1-Deoxy-d-xylulose-5-phosphate synthase (DXS) and 1-deoxy-d-xylulose-5-phosphate reductoisomerase (D...
The development of medical applications exploiting the broad bioactivities of the diterpene therapeu...
Triptolide is a trace natural product of Tripterygium wilfordii. It has antitumor activities, partic...
1. Bioactive compounds from medicinal plants with anticancer and anti-inflammatory effects have beco...
1-Deoxy-d-xylulose-5-phosphate synthase (DXS) and 1-deoxy-d-xylulose-5-phosphate reductoisomerase (D...
Fig. 1. Chemical structures of compounds 1–11.Published as part of Hu, Ya-Lin, Xu, Tian-Qi, Cheng, H...
Farnesylpyrophosphate synthase (FPS) catalyzes the biosynthesis of farnesyl pyrophos-phate (FPP), wh...
Hu, Ya-Lin, Xu, Tian-Qi, Cheng, Huai-Yu, Liu, Ying, Zhang, Xia, Zhang, Yu-Bo, Zhou, Guang-Xiong (202...