Mammalian nuclei are highly organized into functional compartments. Major nuclear processes like DNA replication and RNA processing take place in distinct foci. These microscopically visible foci are formed by the assembly of, for example, DNA replication factors and associated proteins into megadalton complexes often referred to as protein machines or factories. Thus far, two proteins, DNA ligase I and DNA methyltransferase (DNA MTase), have been analyzed in greater detail. In both cases, the assembly process appears to be controlled by distinct targeting sequences that were attached to the catalytic protein core in the course of evolution and mediate the association with replication factories in mammalian cells. The dynamics of these nucl...
Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes ...
Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes ...
Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved ...
Mammalian nuclei are highly organized into functional compartments. Major nuclear processes like DNA...
The mammalian nucleus is highly organized, and nuclear processes such as DNA replication occur in di...
The mammalian nucleus is highly organized, and nuclear processes such as DNA replication occur in di...
Plenty of evidence exists that mammalian nuclei are highly organized. Complex biochemical processes ...
Plenty of evidence exists that mammalian nuclei are highly organized. Complex biochemical processes ...
The mammalian nucleus is highly organized into distinct functional domains separating different bioc...
The mammalian nucleus is highly organized into distinct functional domains separating different bioc...
DNA replication occurs in microscopically visible complexes at discrete sites (replication foci) in ...
Abstract Though there are no separating membranes within the nucleus, different factors are often co...
DNA replication occurs in microscopically visible complexes at discrete sites (replication foci) in ...
DNA replication occurs in microscopically visible complexes at discrete sites (replication foci) in ...
Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes ...
Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes ...
Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes ...
Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved ...
Mammalian nuclei are highly organized into functional compartments. Major nuclear processes like DNA...
The mammalian nucleus is highly organized, and nuclear processes such as DNA replication occur in di...
The mammalian nucleus is highly organized, and nuclear processes such as DNA replication occur in di...
Plenty of evidence exists that mammalian nuclei are highly organized. Complex biochemical processes ...
Plenty of evidence exists that mammalian nuclei are highly organized. Complex biochemical processes ...
The mammalian nucleus is highly organized into distinct functional domains separating different bioc...
The mammalian nucleus is highly organized into distinct functional domains separating different bioc...
DNA replication occurs in microscopically visible complexes at discrete sites (replication foci) in ...
Abstract Though there are no separating membranes within the nucleus, different factors are often co...
DNA replication occurs in microscopically visible complexes at discrete sites (replication foci) in ...
DNA replication occurs in microscopically visible complexes at discrete sites (replication foci) in ...
Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes ...
Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes ...
Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes ...
Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved ...