Deletions in chromosome (chr.) 13q occur frequently in head and neck squamous cell carcinoma (HNSCC). Previous studies failed to identify common deleted regions in chr.13q, though several candidate tumour suppressor genes (TSGs) loci, e.g. BRCA2, RB1 and BRCAX have been localized in this chromosome, as well as no prognostic significance of the deletion has been reported. Thus, in the present study, deletion mapping of chr. 13q has been done in 55 primary HNSCC samples of Indian patients using 11 highly polymorphic microsatellite markers of which three were intragenic to BRCA2 gene, one intragenic to RB1 gene and another from BRCAX locus. The deletion in chr.13q was significantly associated with progression of HNSCC. High frequencies (27–39%...
In the deletion mapping of chromosome (chr) 9 in head and neck lesions of the Indian patient populat...
Purpose: The aim of this study was to analyse the alterations of the genes in the CDKN2A/CCND1/CDK4/...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Deletions in chromosome (chr.) 13q occur frequently in head and neck squamous cell carcinoma (HNSCC)...
Deletions in chromosome (chr.) 13q occur frequently in head and neck squamous cell carcinoma (HNSCC...
Background & Objectives: Deletions in chromosome 8 (chr.8) have been shown to be necessary for t...
Several chromosome regions exhibit loss of heterozygosity (LOH) in human breast carcinoma and are th...
Loss of heterozygosity (LOH) on chromosome 13q is one of the most common genetic alterations in hepa...
The karyotypes of the HNSCC tumours are complex often near triploid and are composed of multiple nu...
The candidate tumor suppressor genes’ (TSG) loci on human chromosome 3 (chr.3) were mapped in six dy...
Background: Genetic instability of chromosome 11 is a frequent event in many solid tumours, includin...
Purpose: Allelic loss is the most frequently genetic alteration found in hepatocellular carcinoma (H...
Head and neck squamous cell carcinoma (HNSCC) is a diverse group of cancers that are frequently aggr...
Loss of heterozygosity (LOH) was analysed in 84 primary tumours from sporadic, familial and heredita...
Allelic losses of chromosome 13 are often detected in nasopharyngeal carcinoma (NPC) and other cance...
In the deletion mapping of chromosome (chr) 9 in head and neck lesions of the Indian patient populat...
Purpose: The aim of this study was to analyse the alterations of the genes in the CDKN2A/CCND1/CDK4/...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Deletions in chromosome (chr.) 13q occur frequently in head and neck squamous cell carcinoma (HNSCC)...
Deletions in chromosome (chr.) 13q occur frequently in head and neck squamous cell carcinoma (HNSCC...
Background & Objectives: Deletions in chromosome 8 (chr.8) have been shown to be necessary for t...
Several chromosome regions exhibit loss of heterozygosity (LOH) in human breast carcinoma and are th...
Loss of heterozygosity (LOH) on chromosome 13q is one of the most common genetic alterations in hepa...
The karyotypes of the HNSCC tumours are complex often near triploid and are composed of multiple nu...
The candidate tumor suppressor genes’ (TSG) loci on human chromosome 3 (chr.3) were mapped in six dy...
Background: Genetic instability of chromosome 11 is a frequent event in many solid tumours, includin...
Purpose: Allelic loss is the most frequently genetic alteration found in hepatocellular carcinoma (H...
Head and neck squamous cell carcinoma (HNSCC) is a diverse group of cancers that are frequently aggr...
Loss of heterozygosity (LOH) was analysed in 84 primary tumours from sporadic, familial and heredita...
Allelic losses of chromosome 13 are often detected in nasopharyngeal carcinoma (NPC) and other cance...
In the deletion mapping of chromosome (chr) 9 in head and neck lesions of the Indian patient populat...
Purpose: The aim of this study was to analyse the alterations of the genes in the CDKN2A/CCND1/CDK4/...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...