The purpose of this chapter is to add knowledge to the still under-investigated relationship between the work-family conflict (WFC) and the overall level of wellbeing pursued by women entrepreneurs. WFC, in particular, may start because work responsibilities interfere with family responsibilities (WIF) and/or when family responsibilities interfere with work demands (FIW). In this study we study if and how WIF and FIW affect women entrepreneurs’ wellbeing. In doing so, a validated questionnaire was administered to 511 women entrepreneurs in Italy. Results show that the conflict between work and family is a key aspect able to affect the overall wellbeing of women entrepreneurs. Data provide evidence that Italian women entrepreneurs present ...