Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models
- Bottini M.
- Mebarek S.
- Anderson K. L.
- Strzelecka-Kiliszek A.
- Bozycki L.
- Simao A. M. S.
- Bolean M.
- Ciancaglini P.
- Pikula J. B.
- Pikula S.
- Magne D.
- Volkmann N.
- Hanein D.
- Millan J. L.
- Buchet R.
DOIAbstract
Matrix vesicles (MVs) are released from hypertrophic chondrocytes and from mature osteoblasts, the cells responsible for endochondral and membranous ossification. Under pathological conditions, they can also be released from cells of non-skeletal tissues such as vascular smooth muscle cells. MVs are extracellular vesicles of approximately 100-300nm diameter harboring the biochemical machinery needed to induce mineralization
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