Fasting promotes longevity by reprogramming metabolic and stress resistance pathways. However, although the impact on adipose tissue physiology through hormonal inputs is well established, the direct role of fasting on adipose cells is poorly understood. Herein we show that white and beige adipocytes, as well as mouse epididymal and subcutaneous adipose depots, respond to nutrient scarcity by acquiring a brown-like phenotype. Indeed, they improve oxidative metabolism through modulating the expression of mitochondrial- and nuclear-encoded oxidative phosphorylation genes as well as mitochondrial stress defensive proteins (UCP1, SOD2). Such adaptation is placed in a canonical mitohormetic response that proceeds via mitochondrial reactive oxyge...
Obesity is a disorder of energy imbalance in which energy intake exceeds energy expenditure (EEX). B...
The functional state of the mitochondrion, the organelle responsible for generating the cellular fue...
Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white...
Fasting promotes longevity by reprogramming metabolic and stress resistance pathways. However, altho...
Proper adipose tissue function controls energy balance with favourable effects on metabolic health a...
Objective: Mitochondria play pivotal roles in orchestrating signaling pathways in order to guarantee...
Finding new molecular pathways and strategies modulating lipolysis in adipocytes is an attractive go...
Forkhead box O class proteins (FoxOs) are expressed nearly in all tissues and are involved in differ...
BACKGROUND: Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, w...
SummaryObesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, ...
Summary: The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeo...
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the...
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the...
Obesity is a disorder of energy imbalance in which energy intake exceeds energy expenditure (EEX). B...
The functional state of the mitochondrion, the organelle responsible for generating the cellular fue...
Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white...
Fasting promotes longevity by reprogramming metabolic and stress resistance pathways. However, altho...
Proper adipose tissue function controls energy balance with favourable effects on metabolic health a...
Objective: Mitochondria play pivotal roles in orchestrating signaling pathways in order to guarantee...
Finding new molecular pathways and strategies modulating lipolysis in adipocytes is an attractive go...
Forkhead box O class proteins (FoxOs) are expressed nearly in all tissues and are involved in differ...
BACKGROUND: Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, w...
SummaryObesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, ...
Summary: The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeo...
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the...
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the...
Obesity is a disorder of energy imbalance in which energy intake exceeds energy expenditure (EEX). B...
The functional state of the mitochondrion, the organelle responsible for generating the cellular fue...
Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white...