Add to ORKGTAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an alternative interpretation of the accumulating data linking p73 to cellular metabolism: we suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation
TAp63α is a member of the p53 family, which plays a central role in epithelial cancers. Recently, a ...
p73, like its homologue, the tumor suppressor p53, is able to induce apoptosis in several cell types...
TAp63α is a member of the p53 family, which plays a central role in epithelial cancers. Recently, a ...
TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a ...
Metabolic adaptation has emerged as a hallmark of cancer and a promising therapeutic target, as rapi...
The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice result...
The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice result...
The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice result...
Abstract During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue h...
p73, like its homologue, the tumor suppressor p53, is able to induce apoptosis in several cell types...
TAp63α is a member of the p53 family, which plays a central role in epithelial cancers. Recently, a ...
p73, like its homologue, the tumor suppressor p53, is able to induce apoptosis in several cell types...
TAp63α is a member of the p53 family, which plays a central role in epithelial cancers. Recently, a ...
TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a ...
Metabolic adaptation has emerged as a hallmark of cancer and a promising therapeutic target, as rapi...
The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice result...
The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice result...
The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice result...
Abstract During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue h...
p73, like its homologue, the tumor suppressor p53, is able to induce apoptosis in several cell types...
TAp63α is a member of the p53 family, which plays a central role in epithelial cancers. Recently, a ...
p73, like its homologue, the tumor suppressor p53, is able to induce apoptosis in several cell types...
TAp63α is a member of the p53 family, which plays a central role in epithelial cancers. Recently, a ...