Intratumoral delivery of recombinant vaccinia virus encoding for ErbB2/Neu inhibits the growth of salivary gland carcinoma cells
- Masuelli, L
- Fantini, M
- Benvenuto, M
- Sacchetti, P
- Tresoldi, I
- Lido, P
- Lista, F
- Cavallo, F
- Nanni, P
- Schlom, J
- GIGANTI, MARIA GABRIELLA
- MODESTI, ANDREA
- BEI, ROBERTO
Publication date
January 2014
DOI Publisher
Springer Science and Business Media LLCAbstract
The antitumor activity induced by intratumoral vaccination with poxvirus expressing a tumor antigen was shown to be superior to that induced by subcutaneous vaccination. Salivary gland carcinomas overexpress ErbB2. Trastuzumab, a monoclonal antibody to ErbB2, was proposed for salivary gland tumors treatment. We explored the effectiveness of intratumoral vaccination with the recombinant vaccinia virus ErbB2/Neu (rV-neuT) vaccine in hampering the growth of transplanted Neu-overexpressing BALB-neuT salivary gland cancer cells (SALTO) in BALB-neuT mice
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