Middle latency components in response to clicks and to low- and middle-frequency tone pips

Middle-latency auditory components (MLC) in response to clicks and tone pips have been recorded in 20 normal subjects, aged between 26 and 32 years, in order to verify their reliability in response to frequency-specific stimuli (0.5 and 1kHz). The results indicate a good reliability of MLC obtained when using tone pips. The responses show the conventionally labeled Po, Na, Nb, Pb waves. The latencies of these waves tend to be greater than those of the corresponding waves elicited by clicks and their amplitudes are smaller. This is probably due to an asynchrony of the responses. The Po and Pa waves are the most resistant to decreasing stimulus intensity, as both are clearly detectable down to 20 dB nHL, but Po is the best threshold index because at 20 dB it has a more clear-cut shape than Pa. According to the latency values obtained for MLC elicited by both clicks and tone pips, the Po wave is probably generated at the inferior colliculus level. The latency shift towards the click-elicited Jewett wave V is mainly due to the different filter settings employed. The morphology of MLC elicited by tone pips is less affected by changes in stimulus frequency than that of corresponding auditory brainstem responses. Thus, MLC are a reliable indicator for defining low- and middle-frequency auditory thresholds