This paper proposes a modeling system developed in order to analyze the urban freight transport and logistics within urban and metropolitan areas. A review of models developed to simulate this segment of mobility is also reported. The review analysis highlights the limits of models for the ex-ante assessment of city logistics measures. For this reason this paper proposes a new modeling system approach for the assessment of city logistics measures. It is made of different steps approaching problems related to: quantity OD flows, restocking type OD flows, delivery OD flows, delivery OD flows for vehicle type and vehicle OD flows. This modeling system has been specified and calibrated using some surveys car-ried out in the inner area of Rome w...