Topics
alkaloidBand
hydrideChemical compound
carbanionChemical compound
sodiumChemical substance
total synthesisProgramming language
The use of Reissert compounds as intermediates for the synthesis of 1-benzylisoquinolines has been investigated. An improved method, utilising sodium hydride, for the generation of the carbanion of Reissert compounds and subsequent reaction with benzyl halides has been found and demonstrated to be a general procedure. This method has been successfully applied as the key stage in providing a new total synthesis of the alkaloid petaline. The stereochemistry of the Reissert compound system has been elucidated by spectroscopic techniques
This research was carried out to obtain a convenient route for the synthesis of [7_ 14C]-p-hydroxy ...
Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in dru...
Carbenium ions generated from substituted benzhydryls using acid catalysis undergo smooth intramolec...
The use of Reissert compounds as intermediates for the synthesis of 1-benzylisoquinolines has been i...
1-(0- and m-Ohlorobenzoyl)isoquinolines have been synthesized by two routes involving Reissert comp...
Part 1 Treatment of the chlorohydrin (49), of the Reissert compound, 2-acetyl-l-cyano-1,2-dihydroiso...
Approaches to the synthesis of partially hydrogenated 8-ketoisoquinolines have been made via 5,6,7,8...
Petaline, an alkaloid from Leontice leontopetalum, Linn, has been shown by synthetic and degradative...
The thesis reports the first examples of Reissert compounds prepared from the benzimidazole ring sys...
Alkaloids of isoquinoline series represent one of the most vast classes of natural products, that ar...
Carbanion rearrangement studies on selected N-acyl-isoquinoline and -quinoline Reissert compounds ha...
Cyanochlorination and cyanogenation of the hetero-ring of various isoquinolines has been achieved by...
Part I of this work describes a general photochemical cyclization of two series of 1-(2-halobenzyl)-...
The isoquinoline alkaloids form a unique class of compounds, exhibiting biological properties almost...
Bischler-Napieralski (B-N) reaction is undoubtedly one of the most powerful methodologies in organic...
This research was carried out to obtain a convenient route for the synthesis of [7_ 14C]-p-hydroxy ...
Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in dru...
Carbenium ions generated from substituted benzhydryls using acid catalysis undergo smooth intramolec...
The use of Reissert compounds as intermediates for the synthesis of 1-benzylisoquinolines has been i...
1-(0- and m-Ohlorobenzoyl)isoquinolines have been synthesized by two routes involving Reissert comp...
Part 1 Treatment of the chlorohydrin (49), of the Reissert compound, 2-acetyl-l-cyano-1,2-dihydroiso...
Approaches to the synthesis of partially hydrogenated 8-ketoisoquinolines have been made via 5,6,7,8...
Petaline, an alkaloid from Leontice leontopetalum, Linn, has been shown by synthetic and degradative...
The thesis reports the first examples of Reissert compounds prepared from the benzimidazole ring sys...
Alkaloids of isoquinoline series represent one of the most vast classes of natural products, that ar...
Carbanion rearrangement studies on selected N-acyl-isoquinoline and -quinoline Reissert compounds ha...
Cyanochlorination and cyanogenation of the hetero-ring of various isoquinolines has been achieved by...
Part I of this work describes a general photochemical cyclization of two series of 1-(2-halobenzyl)-...
The isoquinoline alkaloids form a unique class of compounds, exhibiting biological properties almost...
Bischler-Napieralski (B-N) reaction is undoubtedly one of the most powerful methodologies in organic...
This research was carried out to obtain a convenient route for the synthesis of [7_ 14C]-p-hydroxy ...
Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in dru...
Carbenium ions generated from substituted benzhydryls using acid catalysis undergo smooth intramolec...
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