Modeling Nitroglycerin-Induced Migraine in Rats

The present research sought to determine whether nitroglycerin (NTG) produced changes in clinically relevant endophenotypes of migraine. Rats were given a single injection of NTG or vehicle with the following dependent measures recorded: Rat Grimace Scale, hot and cold tail flick latency, Rotor-Rod performance, and photophobia and movement in traditional and modified light/dark boxes. NTG increased rat grimace scores but did not produce thermal allodynia nor photophobia. Further, NTG produced paradoxical increases in Rotor-Rod performance and movement. These results demonstrate that a single injection of NTG does not produce behaviors that parallel clinical symptoms of migraine