Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their ability to augment experimental and clinical investigations. Cardiac electrophysiology is one of the most advanced areas, with cardiac modelling and simulation being considered for virtual testing of pharmacological therapies and medical devices. Current models present inconsistencies with experimental data, which limit further progress. In this study, we present the design, development, calibration and independent validation of a human-based ventricular model (ToR-ORd) for simulations of electrophysiology and excitation-contraction coupling, from ionic to whole-organ dynamics, including the electrocardiogram. Validation based on substantial mul...
Aims Develop, calibrate and evaluate with clinical data a human electromechanical modelling and sim...
Ventricular arrhythmias are an important cause of death, and can also be a serious side effect of dr...
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise eth...
Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their abi...
Human-based computational modelling and simulation are powerful tools to accelerate the mechanistic ...
The importance of electrolyte concentrations for cardiac function is well established. Electrolyte v...
The importance of electrolyte concentrations for cardiac function is well established. Electrolyte v...
The aim of our work consists in developing a new model of the human ventricular cardiomyocyte, based...
Sudden cardiac death (SCD) is one of the largest causes of natural mortality throughout the world. S...
Contractility has become one of the main readouts in computational and experimental studies on cardi...
The human heart beats as a result of multiscale nonlinear dynamics coupling subcellular to whole org...
AbstractA computational model of the human left-ventricular epicardial myocyte is presented. Models ...
A decrease in extracellular calcium concentration ([Ca2+]o) prolongs the action potential (AP) in ve...
In silico cardiac myocyte models present powerful tools for drug safety testing and for predicting p...
Cardiac Purkinje cells (PCs) are implicated in lethal arrhythmias caused by cardiac diseases, mutati...
Aims Develop, calibrate and evaluate with clinical data a human electromechanical modelling and sim...
Ventricular arrhythmias are an important cause of death, and can also be a serious side effect of dr...
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise eth...
Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their abi...
Human-based computational modelling and simulation are powerful tools to accelerate the mechanistic ...
The importance of electrolyte concentrations for cardiac function is well established. Electrolyte v...
The importance of electrolyte concentrations for cardiac function is well established. Electrolyte v...
The aim of our work consists in developing a new model of the human ventricular cardiomyocyte, based...
Sudden cardiac death (SCD) is one of the largest causes of natural mortality throughout the world. S...
Contractility has become one of the main readouts in computational and experimental studies on cardi...
The human heart beats as a result of multiscale nonlinear dynamics coupling subcellular to whole org...
AbstractA computational model of the human left-ventricular epicardial myocyte is presented. Models ...
A decrease in extracellular calcium concentration ([Ca2+]o) prolongs the action potential (AP) in ve...
In silico cardiac myocyte models present powerful tools for drug safety testing and for predicting p...
Cardiac Purkinje cells (PCs) are implicated in lethal arrhythmias caused by cardiac diseases, mutati...
Aims Develop, calibrate and evaluate with clinical data a human electromechanical modelling and sim...
Ventricular arrhythmias are an important cause of death, and can also be a serious side effect of dr...
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise eth...