Green alcoholic solvent and UAE extraction of oleuropein from the Olea europaea L.leaves: Experimental design, optimization, and comparison with Pharmacopoeia method

Solvent extraction and UAE were studied for the extraction of the polyphenolic compounds from the olive leaf in MeOH/H 2 O and EtOH/H 2 O solvent systems. Box Wilson-CCRD design was used under RSM for the experimental design of alcoholic solvent extraction. Multi-response optimization was solved with the help of pareto areas and optimal input variable values were determined by the desirability function, optimization by fuzzy similar precedable ratio method. It is seen that the developed solvent extraction methods are more advantageous to the European Pharmacopoeia method for especially oleuropein and the other phenolics which have synergetic effect in olive leaf extract. © 2019, © 2019 Taylor & Francis Group, LLC