Thanks to the advancements in computer power and capability of Computational Fluid Dynamics codes, the amount of research work on the numerical simulation of slurry flows in pipelines has increased exponentially in few years, opening the way to the use of this approach for engineering purposes. The Two Fluid Model (TFM), in which both phases are interpreted as interpenetrating continua and solved in the Eulerian, cell-based framework, allows the best compromise considering the engineering requirements of computational efficiency, applicability, and accuracy. However, the solution of this model is affected by several numerical and modelling factors, and, even if good agreement is achieved between simulation results and experimental measureme...