Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: The RISC study
- De Rooij S. R.
- Dekker J. M.
- Kozakova M.
- Mitrakou A.
- Melander O.
- Gabriel R.
- Guidone C.
- Hojlund K.
- Murphy M. S.
- Nijpels G.
- Dekker J.
- De Rooij S.
- Nijpels G.
- Boorsma W.
- Mitrakou A.
- Tournis S.
- Kyriakopoulou K.
- Thomakos P.
- Lalic N.
- Lalic K.
- Jotic A.
- Lukic L.
- Civcic M.
- Nolan J.
- Yeow T. P.
- Murphy M.
- DeLong C.
- Neary G.
- Colgan M. P.
- Hatunic M.
- Konrad T.
- Bohles H.
- Fuellert S.
- Baer F.
- Zuchhold H.
- Golay A.
- Harsch Bobbioni E.
- Barthassat V.
- Makoundou V.
- Lehmann T. N. O.
- Merminod T.
- Petrie J. R.
- Perry C.
- Neary F.
- MacDougall C.
- Shields K.
- Malcolm L.
- Laakso M.
- Salmenniemi U.
- Aura A.
- Raisanen R.
- Ruotsalainen U.
- Sistonen T.
- Laitinen M.
- Saloranta H.
- Coppack S. W.
- McIntosh N.
- Ross J.
- Pettersson L.
- Khadobaksh P.
- Laville M.
- Bonnet F.
- Brac De La Perriere A.
- Louche-Pelissier C.
- Maitrepierre C.
- Peyrat J.
- Beltran S.
- Serusclat A.
- Gabriel R.
- Sanchez M. E.
- Carraro R.
- Friera A.
- Perez S.
- Nilsson P.
- Persson M.
- Ostling G.
- Melander O.
- Burri P.
- Piatti P. M.
- Monti L. D.
- Setola E.
- Galluccio E.
- Minicucci F.
- Colleluori A.
- Walker M.
- Ibrahim I. M.
- Jayapaul M.
- Carman D.
- Ryan C.
- Short K.
- McGrady Y.
- Richardson D.
- Beck-Nielsen H.
- Staehr P.
- Hojlund K.
- Vestergaard V.
- Olsen C.
- Hansen L.
- Bolli G. B.
- Porcellati F.
- Fanelli C.
- Lucidi P.
- Calcinaro F.
- Saturni A.
- Ferrannini E.
- Natali A.
- Muscelli E.
- Pinnola S.
- Kozakova M.
- Mingrone G.
- Guidone C.
- Favuzzi A.
- Di Rocco P.
- Anderwald C.
- Bischof M.
- Promintzer M.
- Krebs M.
- Mandl M.
- Hofer A.
- Luger A.
- Waldhausl W.
- Roden M.
- Balkau B.
- Coppack S. W.
- Dekker J. M.
- Ferrannini E.
- Mari A.
- Walker M.
- Gaffney P.
- Nolan J.
- Boran G.
- Olsen C.
- Hansen L.
- Beck-Nielsen H.
- Kok A.
- Dekker J.
- Patel S.
- Walker M.
- Gastaldelli A.
- Ciociaro D.
- Kozakova M.
- Guillanneuf M. T.
- Balkau B.
- Mhamdi L.
- Balkau B.
- Balkau B.
- Mari A.
- Mhamdi L.
- Landucci L.
- Hills S.
- Mota L.
- Mari A.
- Pacini G.
- Cavaggion C.
- Hills S. A.
- Landucci L.
- Mota L.
DOIAbstract
Objective: Fasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. Design and methods: The Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic, overall healthy men and women aged 30-60 years. We performed standard oral glucose tolerance tests and hyperinsulinemic euglycemic clamps. As a general measure of cardiovascular risk, we assessed the prevalence of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was measured by ultrasound to assess preclinical atheros...
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