This thesis presents models and methodologies to understand the control of systemic risk in large systems. We propose two approaches. The first one is structural: a financial system is represented as a network of institutions. They have strategic interactions as well as direct interactions through linkages in a contagion process. The novelty of our approach is that these two types of interactions are intertwined themselves and we propose new notions of equilibria for such games and analyze the systemic risk emerging in equilibrium. The second approach is a reduced form. We model the dynamics of regulatory capital using a mean field operator: required capital depends on the standalone risk but also on the evolution of the capital of all othe...