The paper presents an interactive kinematic limit analysis approach that can be handled also by inexperienced users for a reliable evaluation of the seismic vulnerability of masonry towers. The procedure requires only a 3D Computer-Aided Design CAD representation of the tower and the mechanical properties to assign to the different volumes. Five possible failure mechanisms are hypothesized, corresponding to those more frequently observed during post-earthquake surveys. They are all constituted by few macro-blocks mutually roto-translating and the code proposed automatically optimizes the shape of the selected failure mechanisms with a Genetic Algorithm GA approach, minimizing the failure multiplier—in agreement with the upper bound theorem ...