The monoclonal antibody (mAb) market has been presenting a significant growth rate in the last two decades, which increased the interest of biopharmaceutical companies in this product class. Many improvements have been achieved in the upstream processing of mAbs, leading to significant increases in bioreactor titers. However, the production costs are still high, especially due to downstream processing costs, which can represent a major part of the of overall production costs. Traditional mAb platform processes include a very selective, but high-cost Protein A (PrA) affinity chromatography as the first purification step (capture). Several approaches have been recently explored in order to replace PrA chromatography. In this work, we propose ...
Monoclonal antibodies are the largest and most rapidly expanding category of biopharmaceuticals toda...
Perfusion cell culture processes have demonstrated higher productivity than fed-batch due to the abi...
Monoclonal antibodies (mAbs) are large recombinant proteins produced in CHO (Chinese hamster ovary) ...
The monoclonal antibody (mAb) market has been presenting a significant growth rate in the last two d...
Monoclonal antibodies (mAbs) are a predominant modality for a broad range of clinical indications in...
The goal of this work is to establish an intensified downstream scheme for stable, high-titer monocl...
The goal of this work is to establish an intensified downstream scheme for stable, high-titer monocl...
Flocculants have been widely used in the food and chemical industry, as well as in wastewater clarif...
Continuous manufacturing is expected to increase the productivity of protein drug production. Howeve...
Multi-column continuous chromatography (MCC) offers significant economic advantages over traditional...
As downstream process (DSP) of monoclonal antibody (mAb) includes several batch chromatography steps...
Monoclonal antibodies are conquering the biopharmaceutical market because they can be used to treat ...
Precipitation and flocculation are optimal unit operations for continuous capture of proteins from c...
Precipitation and flocculation are optimal unit operations for continuous capture of proteins from c...
Continuous manufacturing is expected to increase the productivity of the production of biologics suc...
Monoclonal antibodies are the largest and most rapidly expanding category of biopharmaceuticals toda...
Perfusion cell culture processes have demonstrated higher productivity than fed-batch due to the abi...
Monoclonal antibodies (mAbs) are large recombinant proteins produced in CHO (Chinese hamster ovary) ...
The monoclonal antibody (mAb) market has been presenting a significant growth rate in the last two d...
Monoclonal antibodies (mAbs) are a predominant modality for a broad range of clinical indications in...
The goal of this work is to establish an intensified downstream scheme for stable, high-titer monocl...
The goal of this work is to establish an intensified downstream scheme for stable, high-titer monocl...
Flocculants have been widely used in the food and chemical industry, as well as in wastewater clarif...
Continuous manufacturing is expected to increase the productivity of protein drug production. Howeve...
Multi-column continuous chromatography (MCC) offers significant economic advantages over traditional...
As downstream process (DSP) of monoclonal antibody (mAb) includes several batch chromatography steps...
Monoclonal antibodies are conquering the biopharmaceutical market because they can be used to treat ...
Precipitation and flocculation are optimal unit operations for continuous capture of proteins from c...
Precipitation and flocculation are optimal unit operations for continuous capture of proteins from c...
Continuous manufacturing is expected to increase the productivity of the production of biologics suc...
Monoclonal antibodies are the largest and most rapidly expanding category of biopharmaceuticals toda...
Perfusion cell culture processes have demonstrated higher productivity than fed-batch due to the abi...
Monoclonal antibodies (mAbs) are large recombinant proteins produced in CHO (Chinese hamster ovary) ...