Suppose H is a separable and complex Hilbert space with a generalized frame (also known as continuous frame) indexed over a metric measure space X. We study the main properties of generalized frames and the operators defined by them, such as concentration operators and Toeplitz operators. Imposing certain localization conditions to the generalized frame, we describe the asymptotic behavior of concentration and Toeplitz operators, and derive important results about the distribution of their eigenvalues. Furthermore, working with multiple generalized frames in H intertwined by a localization conditions, we obtain very general density results. Many examples and applications are shown, among others we obtain necessary density cond...