Stężenia eozynofi lowego białka kationowego w surowicy i plwocinie a stan kliniczny chorych na mukowiscydozę

Recent studies have emphasied the role of eosinophils and it&#8217;s metabolites in the pathogenesis of lung disease in cystic fibrosis. This study was designed to assess the relationship between serum and sputum ECP levels and clinical status of cystic fibrosis patients. Material and methods: 30 patients, aged 6-30 with moderate cystic fibrosis were recruited. Spirometry, weight and high, and Shwachman-Kulczycki score were measured, and serum and sputum samples were obtained for measurements of the eosinophil cationic protein (ECP). Results: We observed significant inverse correlation between sputum ECP levels and BMI (p < 0.001) and FEV1 (p < 0.001), and not significant inverse correlation between sputum ECP levels Shwachman-Kulczycki score (p = 0.057). There was no signifi cant correlation between sputum ECP levels and FEF25/75% and between serum ECP levels and measured clinical parameters. Conclusions: Results of this study suggest influence of eosinophil inflammation in respiratory tract on clinical status of CF patients