The Technology for Carbanazepine Granules by Moist Granulation and the Research into Granule Characteristics

Karbamazepinas yra priešepilepsinis vaistas skirtas židininiams, toniniams-kloniniams epilepsijos priepuoliams malšinti, bei trišakiai neuralgijai gydyti. Tačiau karbamazepinas, vartojamas oraliai, pasižymi gana lėta absorbcija organizme. Drėgnasis granuliavimas yra procesas kurio metu naudojamas skystis kaip surišėjas, kuris sulipina miltelius į granuliatus. Norint gauti granules su geriausiomis charakteristikomis, technologinis procesas bei miltelių sudėtis turi būti tinkamai subalansuoti.Carbamazepine is used to prevent and control seizures. This medication is known as an anticonvulsant or anti-epileptic drug. It is also used to relieve one type of nerve pain (trigeminal neuralgia). Thought, the absorption of carbamazepine, after oral doses, is very slow. Wet granulation is a process of using a liquid binder to lightly agglomerate the powder mixture. The granulation process and composition of powders has to be properly controlled, in case to produce granules with best characteristics. Key words: Carbamazepine, granules, solubility, powders, Tween (polysorbate