Preparation and Evaluation of Carbamazepine Sustained Release Tablets

ABSTRACT: The purpose of the present studies was to develop and characterize sustained release tablets of Carbamazepine, an antiepileptic drug. Tablets were prepared by direct compression method. In the formulation, the active drug was taken 200 mg in every formulation. Methocel K4M, Methocel K15M CR, Methocel K100LV CR, Eudragit RSPO and Eudragit RLPO polymers were used as rate retarding agents in twenty four formulations (F-1 to F-24). The effect of hydrophilic polymer PEG 6000 as channeling agent with Methocel K4M was observed in four formulations (F-5 to F-8). The granules were evaluated for angle of repose, bulk density, tapped density. The tablets were subjected to average weight, diameter, thickness, weight variation, hardness, friability and in vitro dissolution studies. The granules showed satisfactory flow properties, compressibility and drug content. The in vitro dissolution study was carried using USP Apparatus-I (Rotating basket method apparatus) for 6 to 12 hours in distilled water with 1 % sodium lauryl sulphate as the dissolution medium. The release mechanisms were explored and explained by Zero order, First order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell equations. Primarily twelve formulations were prepared by using four variable amount of three polymers; Methocel K4M (50, 100, 150 and 200 mg) in th