Cardiac arrhythmias are a global health burden, contributing significantly to morbidity and mortality worldwide. Despite technological advances in catheter ablation therapy, antiarrhythmic drugs (AADs) remain a cornerstone for the management of cardiac arrhythmias. Experimental and translational studies have shown that commonly used AADs exert multiple effects in the heart, the manifestation of which strongly depends on the exact experimental or clinical conditions. This diversity makes the optimal clinical application of AADs challenging. Here, we present a novel computational tool designed to facilitate a better understanding of the complex mechanisms of action of AADs (the Maastricht Antiarrhythmic Drug Evaluator, MANTA). In this tool, w...
Reverse rate dependence is a problematic property of antiarrhythmic drugs that prolong the cardiac a...
Ventricular arrhythmias are a major cause of sudden cardiac death, which accounts for about 50% of c...
<div><p>Anti-arrhythmic drug therapy is a frontline treatment for atrial fibrillation (AF), but its ...
Cardiac arrhythmias are a global health burden, contributing significantly to morbidity and mortalit...
Cardiac arrhythmias are a global health burden, contributing significantly to morbidity and mortalit...
Antiarrhythmic treatment strategies remain suboptimal due to our inability to predict how drug inter...
Introduction: Although there have been important technological advances for the treatment of cardiac...
Introduction: Although there have been important technological advances for the treatment of cardiac...
Sudden cardiac death (SCD) is one of the largest causes of natural mortality throughout the world. S...
Abstract Cardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities ...
Concerns over cardiac side effects are the largest single cause of compound attrition during pharmac...
Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major c...
Antiarrhythmic drugs, designed to prevent or suppress cardiac arrhythmias, may cause the worsening o...
Vernakalant is a new antiarrhythmic agent for the treatment of atrial fibrillation. While it has pro...
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise eth...
Reverse rate dependence is a problematic property of antiarrhythmic drugs that prolong the cardiac a...
Ventricular arrhythmias are a major cause of sudden cardiac death, which accounts for about 50% of c...
<div><p>Anti-arrhythmic drug therapy is a frontline treatment for atrial fibrillation (AF), but its ...
Cardiac arrhythmias are a global health burden, contributing significantly to morbidity and mortalit...
Cardiac arrhythmias are a global health burden, contributing significantly to morbidity and mortalit...
Antiarrhythmic treatment strategies remain suboptimal due to our inability to predict how drug inter...
Introduction: Although there have been important technological advances for the treatment of cardiac...
Introduction: Although there have been important technological advances for the treatment of cardiac...
Sudden cardiac death (SCD) is one of the largest causes of natural mortality throughout the world. S...
Abstract Cardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities ...
Concerns over cardiac side effects are the largest single cause of compound attrition during pharmac...
Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major c...
Antiarrhythmic drugs, designed to prevent or suppress cardiac arrhythmias, may cause the worsening o...
Vernakalant is a new antiarrhythmic agent for the treatment of atrial fibrillation. While it has pro...
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise eth...
Reverse rate dependence is a problematic property of antiarrhythmic drugs that prolong the cardiac a...
Ventricular arrhythmias are a major cause of sudden cardiac death, which accounts for about 50% of c...
<div><p>Anti-arrhythmic drug therapy is a frontline treatment for atrial fibrillation (AF), but its ...