This paper examines the history of the Yup\u27ik Eskimos of western Alaska and explores how their shamans shaped the response to introduced epidemic disease. As in the experiences of so many other Native American groups, disease epidemics played an important role in the history of relations between the Yup\u27ik Eskimos and white settlers in the nineteenth and twentieth centuries. I argue here that while the Yup\u27ik Eskimos grappled with the devastating effects of introduced diseases, they did not repudiate their shamans and traditional faith, which sets the Yup\u27ik people apart from other Native Americans. Before contact with Europeans, the Yup\u27ik people relied on their shamans for physical and psychological healing. Despite challen...