The ability to make decisions about different risks and rewards appears to recruit a neural circuit that includes the prefrontal cortex (PFC), the amygdala and the ventral striatum. The present thesis used a combination of behavioural, statistical, anatomical, and pharmacological techniques to elucidate the nature of risk-based decision making and the underlying neural circuits and neuromodulatory systems that contribute to this form of behaviour. Chapter 2 examined probabilistic discounting as a model of risk-based decision making. Statistical modeling revealed substantial individual variability in discounting of large, probabilistic rewards in well-trained animals which develops over the course of training. These discounting patterns were...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
International audienceIn uncertain and changing environments, optimal decision-making requires integ...
RATIONALE: During value-based decision-making, organisms make choices on the basis of reward expecta...
The ability to make decisions about different risks and rewards appears to recruit a neural circuit ...
ii The ability to make decisions about different risks and rewards appears to recruit a neural circu...
Damage to various regions of the prefrontal cortex (PFC) impairs decision making involving evaluatio...
Making a risky decision is a complex process that involves evaluation of both the value of the optio...
Weighing the value of a reward against its likelihood of delivery is a necessary component of adapti...
Weighing the value of a reward against its likelihood of delivery is a necessary component of adapti...
Dopamine, acting via different modes of transmission, is involved in making cost-benefit decisions i...
Dopamine, acting via different modes of transmission, is involved in making cost-benefit decisions i...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
Rationale: During value-based decision-making, organisms make choices on the basis of reward expecta...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
International audienceIn uncertain and changing environments, optimal decision-making requires integ...
RATIONALE: During value-based decision-making, organisms make choices on the basis of reward expecta...
The ability to make decisions about different risks and rewards appears to recruit a neural circuit ...
ii The ability to make decisions about different risks and rewards appears to recruit a neural circu...
Damage to various regions of the prefrontal cortex (PFC) impairs decision making involving evaluatio...
Making a risky decision is a complex process that involves evaluation of both the value of the optio...
Weighing the value of a reward against its likelihood of delivery is a necessary component of adapti...
Weighing the value of a reward against its likelihood of delivery is a necessary component of adapti...
Dopamine, acting via different modes of transmission, is involved in making cost-benefit decisions i...
Dopamine, acting via different modes of transmission, is involved in making cost-benefit decisions i...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
Rationale: During value-based decision-making, organisms make choices on the basis of reward expecta...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
Converging evidence from human and animal studies suggests that decision-making relies upon a distri...
International audienceIn uncertain and changing environments, optimal decision-making requires integ...
RATIONALE: During value-based decision-making, organisms make choices on the basis of reward expecta...